Junyan Liu

 

Tel: (530) 752-5109
Fax: (530) 752-8995

Email: jynliu@ucdavis.edu; jyliujs@gmail.com

Education

Ph.D. conferred, June 2003 from Nanjing University, Nanjing, China, major in Natural Products Chemistry

Master’s degree conferred, July 2000 from Northwest Sci-Tech University of Agriculture & Forestry, Yangling, China, major in Phytochemistry

Bachelor’s degree conferred, June 1994 from Nanjing Institute of Chemical & Industrial Technology, Nanjing, China, major in Polymer Materials

Ongoing Projects & Research Interest

1) Pharmacokinetics and pharmacodynamics study of sEHi on mice, rats and so on;
2) Investigation of the possibly synergistic effect between sEH inhibitor and COX/LOX inhibitors using metabolomics method;
3) Development of the novel analytic methods to quantify the antioxidant using array of liquid chromatography coupled with mass spectrometry methods;
4) Development of a bioassay method to evaluate the inhibitory effect of dual inhibitors (sEH and COX) using oxylipin profiling of culture whole blood;
5) Characterization and quantitation of structurally novel and bioactively significant secondary metabolites from medicinal plants and specially harboring microorganisms such as marine microorganisms and endophytic fungus.

Selected Publications

Liu J. Y., Huang L. L., Ye Y. H., Zou W. X., Guo Z. J., Tan R. X. (2006) Antifungal and new metabolites of Myrothecium sp. Z16, a symbiotic fungus in Argyrosomus argentatus. J. Appl. Microbiol. 100: 195-202

Jiao R. H., Xu S., Liu J. Y., Ge H. M., Ding H., Xu C., Zhu H. L., Tan R. X. (2006) Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp IFB-E015. Org. Lett. 8: 5709-5712

Liu J. Y., Ye Y. H., Wang L., Shi D. H., Tan R. X. (2005) New resveratrol oligomers from the stem bark of Hopea hainanensis. Helv. Chim. Acta. 88: 2910-2917

Ye Y. H., Zhu H. L., Song Y. C., Liu J. Y., Tan R. X. (2005) Structural revision of aspernigrin A, reisolated from Cladosporium herbarum IFB-E002. J. Nat. Prod. 68: 1106-1108

Li Y., Song Y. C., Liu J. Y., Ma Y. M., Tan R. X. (2005) Anti-Helicobacter pylori substances from endophytic fungal cultures. World J. Microbio. & Biotech. 21: 553-558

Li Y., Xu C., Zhang Q. A., Liu J. Y., Tan R. X. (2005) In vitro anti-Helicobacter pylori action of 30 Chinese herbel medicines used to treat ulcer diseases. J. Ethnopharmacol. 98: 329-333.

Liu J. Y., Song Y. C., Zhang Z., Wang L., Guo Z. J., Zou W. X., Tan R. X. (2004) Aspergillus fumigatus CY018, an endophytic fungus in Cynodon dactylon as a versatile producer of new and bioactive metabolites. J. Biotech. 114: 279-287

Zhao Y., Liu J. Y., Wang J., Wang L., Yin H., Tan R. X., Xu Q. (2004) Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-a production and lymphocyte adhesion to extracellular matrices. J. Pharm. Pharmacol. 56:775-782

Ma Y. M., Li Y., Liu J. Y., Song Y. C., Tan R. X. (2004) Anti-Helicobacter pylori metabolites from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon. Fitoterapia 75, 451-456

Chen J. H., Cui G. Y., Liu J. Y., Tan R. X. (2003) Pinelloside, a new antimicrobial cerebroside from Pinellia ternate. Phytochemistry 64: 903-6

Liu J. Y., Liu C. H., Zou W. X., Tan R. X. (2003) Leptosphaeric Acid, a metabolite with a novel skeleton from Leptosphaeria sp. IV403, an endophytic fungus in Artemisia annua. Helv. Chim. Acta 86: 657-660

Zhou C. X., Liu J. Y., Ye W. C., Liu C. H., Tan R. X. (2003) Neoverataline A and B, two antifungal alkaloids with a novel carbon skeleton from Veratrum taliense. Tetrahedron 59: 5743-5747

Liu C. H., Liu J. Y., Huang L. L., Zou W. X., Tan R. X. (2003) Absolute configuration of keisslone, a new antimicrobial metabolite from Keisslerriella sp. YS4108, a marine filamentous fungus. Planta Medica 69: 481-483

Cui G. Y., Liu J. Y., Tan R. X. (2003) A new antimicrobial flavonol glycoside from Alchornea davidii. Chin. Chem. Lett. 14:179-180

Liu J. Y., Liu C. H., Zou W. X., Tian X., Tan R. X. (2002) Leptosphaerone, a metabolite with a novel skeleton from Leptosphaeria sp. IV403, an endophytic fungus in Artemisia annua. Helv. Chim. Acta 85:2664-2667.