Junyan
Liu
Assistant
Project Scientist
Tel: +1-530-752-5109 (o) Fax: +1-530-752-1537
Email: jyliujs@gmail.com, jynliu@ucdavis.edu,
EDUCATION
• PhD, June 2003 from the School of Life Sciences, Nanjing
University, Nanjing, China
• MS, July 2000
from the School of Life Sciences, Northwest Sci-Tech University
of Agriculture & Forestry, Yangling, China
• BE, June 1994
from the Department of Chemical Engineering, Nanjing Institute of
Chemical & Industrial Technology, Nanjing, China
EXPERIENCE
• Jun. 2009 to present Assistant Project Scientist in Department
of Entomology, University of California at Davis. Working in the
field of Metabolomics, Pharmacokinetics and Natural Medicinal Chemistry
• May 2005 to
May 2009 Postgraduate Researcher in Department of Entomology with
Prof. Bruce D. Hammock, University of California at Davis. Working
in the field of Metabolomics, Pharmacokinetics and Natural Medicinal
Chemistry
• Jun., 2003-Apr.,
2005 Postdoctoral fellow in State Key Laboratory of Coordination
Chemistry, Nanjing University. Worked in the field of Natural Medicinal
Chemistry
RESEARCH
FIELDS
• Metabolomics
1) Using metabolic profiling
and related biological approaches to test the role and function
of oxylipin mediators derived from arachidonic acid, docosahexaenoic
acid (DHA), eicosapentaenoic acid (EPA) mediated with cyclooxygenases
(COXs), lipoxygenases (LOXs) and cytochrome P450s (CYP450s) in animal
disease models;
2) Using metabolic profiling
and related biological approaches to test the possible interactions
among the branches of COXs, LOXs, and CYP450s by selective modulation
of specific branches in animal models;
3) Using global fingerprinting
and metabolic profiling and related biological approaches to test
the hypotheses and identify the new biomarker(s) in human and/or
animal models.
• Pharmacokinetics
Investigation of the
absorption, distribution, metabolism and excretion (ADME) of drugs
in multiple animal models.
• Natural Medicinal Chemistry
Identification of structurally
novel and bioactively significant compounds from natural materials
(plants and microorganisms)
SELECTED PUBLICATIONS
1. Liu JY, Park SH, Morisseau
C, Hwang SH, Hammock BD and Weiss RH. (2009) Sorafenib has sEH inhibitory
activity which contributes to its effect profile in vivo. Mol Cancer
Ther 8: 2193-2203
2. Liu JY, Tsai HJ, Hwang
SH, Jones PD, Morisseau C and Hammock BD. (2009) Pharmacokinetic
optimization of four soluble epoxide hydrolase inhibitors for use
in a murine model of inflammation. Brit. J. Pharmacol. 156: 284-296
3. Hu SC, Hong K, Song
YC, Liu JY and Tan RX. (2009) Biotransformation of soybean isoflavones
by a marine Streptomyces sp. 060524 and cytotoxicity of the products.
World J Microbio Biotechnol. 25: 115-121
4. Hwang SH, Tsai HJ,
Liu JY, Morisseau C and Hammock BD. (2007) Orally bioavailable potent
soluble epoxide hydrolase inhibitors. J. Med. Chem. 50: 3825-40
5. Jiao RH, Xu S, Liu
JY, Ge HM, Ding H, Xu C, Zhu HL and Tan RX. (2006) Chaetominine,
a cytotoxic alkaloid produced by endophytic Chaetomium sp IFB-E015.
Org. Lett. 8: 5709-12
6. Liu JY, Huang LL,
Ye YH, Zou WX, Guo ZJ and Tan RX. (2006) Antifungal and new metabolites
of Myrothecium sp. Z16, a fungus associated with white croaker Argyrosomus
argentatus. J. Appl. Microbiol. 100: 195-202
7. Liu JY, Ye YH, Wang
L, Shi DH and Tan RX. (2005) New resveratrol oligomers from the
stem bark of Hopea hainanensis. Helv. Chim. Acta 88: 2910-7
8. Ye YH, Zhu HL, Song
YC, Liu JY and Tan RX. (2005) Structural revision of aspernigrin
A, reisolated from Cladosporium herbarum IFB-E002. J. Nat. Prod.
68: 1106-8
9. Li Y, Song YC, Liu
JY, Ma YM and Tan RX. (2005) Anti-Helicobacter pylori substances
from endophytic fungal cultures. World J. Microb. Biot. 21: 553-8
10. Li Y, Xu C, Zhang
Q, Liu JY and Tan RX. (2005) In vitro anti-Helicobacter pylori action
of 30 Chinese herbel medicines used to treat ulcer diseases. J.
Ethnopharmacol. 98: 329-33
11. Liu JY, Song YC,
Zhang Z, Wang L, Guo ZJ, Zou WX and Tan RX. (2004) Aspergillus fumigatus
CY018, an endophytic fungus in Cynodon dactylon as a versatile producer
of new and bioactive metabolites. J. Biotech. 114: 279-87
12. Ma YM, Li Y, Liu
JY, Song YC, Tan RX. (2004) Anti-Helicobacter pylori metabolites
from Rhizoctonia sp. Cy064, an endophytic fungus in Cynodon dactylon.
Fitoterapia 75, 451-6
13. Zhao Y, Liu JY,
Wang J, Wang L, Yin H, Tan RX and Xu Q. (2004) Fumigaclavine C improves
concanavalin A-induced liver injury in mice mainly via inhibiting
TNF-a production and lymphocyte adhesion to extracellular matrices.
J. Pharm. Pharmacol. 56:775-82
14. Chen JH, Cui GY,
Liu JY and Tan RX. (2003) Pinelloside, a new antimicrobial cerebroside
from Pinellia ternate. Phytochemistry 64: 903-6
15. Liu JY, Liu CH, Zou
WX and Tan RX. (2003) Leptosphaeric Acid, a metabolite with a novel
skeleton from Leptosphaeria sp. IV403, an endophytic fungus in Artemisia
annua. Helv. Chim. Acta 86: 657-60
16. Zhou CX, Liu JY,
Ye WC, Liu CH and Tan RX. (2003) Neoverataline
A and B, two antifungal alkaloids with a novel carbon skeleton from
Veratrum taliense. Tetrahedron 59: 5743-7
17. Liu CH, Liu JY,
Huang LL, Zou WX and Tan RX. (2003) Absolute configuration of keisslone,
a new antimicrobial metabolite from Keisslerriella sp. YS4108, a
marine filamentous fungus. Planta Medica 69: 481-483
18. Cui GY, Liu JY and
Tan RX. (2003) A new antimicrobial flavonol glycoside from Alchornea
davidii. Chin. Chem. Lett. 14:179-80
19. Liu JY, Liu CH,
Zou WX, Tian X and Tan RX. (2002) Leptosphaerone, a metabolite with
a novel skeleton from Leptosphaeria sp. IV403, an endophytic fungus
in Artemisiaannua. Helv. Chim. Acta 85:2664-7
