Jozsef
Lango
Mass
Spectrometry Specialist & Lecturer
Tel:
(530) 752-0312
Fax:
(530)
752-8995
email:
Education
M.S., Chemistry,
Eötvös Univetsity, Budapest, 1977
University Doctor, Inorganic Chemistry, Eötvös Univetsity,
Budapest, 1981
M.S., Spectroscopic Sciences, Technical University, Budapest, 1984
Postdoctoral Fellow, Mount Sinai School of Medicine, New York, 1990-92
B.S., Physical Education, Univetsity of Physical Education, Budapest,
1992
Ph.D., Chemistry, Eötvös Univetsity, Budapest, 1995
H. H. Humphrey
Fellow, Johns Hopkins University, Baltimore, 1997-98
Head, Department of Spectroscopy, Institute for Drug Research, Budapest,
1998
Appointed to faculty, UC Davis, 1999-
Award, President of United States, 1998
Research
• Study of the mass spectral behavior of organometallic compounds
under electron impact.
• Development of mathematical methods to increase the structural
information obtainable from the electron impact mass spectra of
organic compounds.
• Classification and structural elucidation of organic compounds:
antibiotics, alkaloids, nucleosides, nucleotides, steroids, amino
acids, carbohydrates and various heterocyclics.
• Investigation of in vivo metabolites of candidate drugs
(antiflammatories, tranquilizers etc.) in rat, dog and monkey. Study
on pulmonary and IP metabolic process of naphthalene in mice.
• Identification of drug decomposition products and participation
in method development to increase the stability of drug preparations.
• Development of analytical techniques for the trace level
quantification of antineoplastic and antiviral drugs in blood and
other body fluids. Detection, identification, and quantification
of circulating biochemical markers of microorganisms causing opportunistic
infections in immunosuppressed cancer and AIDS patients. Mass spectrometry-mass
spectrometry (MS/MS) studies on the decomposition, structure, and
potential metabolites of antineoplastic agents (plant alkaloids).
• Mass spectral sequencing of bioactive peptides, oligo-peptides
and both wild type and recombinant proteins (e.g. hirudin, calcitonin).
• Classification and structural elucidation of noval antifungal
agents.
• Molecular modeling of oligo-peptides, proteins and other
synthetic compounds using molecular mechanics, semi empirical and
ab initio methods for the estimated energy, geometry, conformation,
charge density calculations of molecules, ions and radicals involved
in mass spectrometric investigations using Spartan molecule modeling
software.
• Study of peptide (protein) digest processes, developing
method to decrease the uncertaincy of classification of peptides
based on their digest products.
• Characterize of complex natural products - peptide (protein)
components of venom from scorpion Parabuthus transvaalicus by different
mass spectroscopic methods
• Develop analytical methods for metabolomics’ studies
using human specimens with focus on autism
• Classify and elucidate structures of novel compounds of
biological or synthetic origin, develop analytical methods and provide
technical training and support to members of the UC Davis Superfund
Program Project Group.
Publications
Jerkovich, Gy., Horváth, Gy. and Langó, J., Combinatorial
Information Content of Mass Spectra., Int. J. Mass Spectr. Ion Phys.,
47, 329-332, (1983). [PDF]
Langó, J., Szepes, L., Császár, P. and Innorta,
G., Studies on Unimolecular Decomposition Processes of Organometallic
Ions, Int. J. Organometall. Chem., 269, 133-145, (1984). [PDF]
Szilágyi, G., Sohár, P., Langó, J. and Zólyomi,
G., Cyclisations of 1-methyl-1-(3-Pyridazinyl) Hydrazones, Tetrahedron,
45, 1793-1800, (1989). [PDF]
Szilágyi, G., Somorai, T., Bozó, É., Langó,
J., Nagy, G., Reiter, J., Janáky, J. and Andrási,
F., Preparation and Antiarthitic Activity of New 1,5-diaryl- alkylthio-1H-1,2,4-triazoles
and corresponding sulfoxides and sulfones, Eur. J. Med. Chem., 25,
95-101, (1990). [PDF]
Langó, J., Roboz, J. and Holland J. F., Collisional Activation
Decomposition (CAD) of Vinca Alkaloids using FAB and Tandem Mass
Spectrometry, (Extended Abstract), 39th ASMS Conf. on Mass Spectrom.,
Allied Topics, 1185-1186 (1991). [PDF]
Jerkovich, Gy. and Langó, J., Application of Information
Theory in Mass Spectrometry, Acta Chim. Hung., 128, 157-161, (1991).
[PDF]
Prókai, L., Prókai-Tátrai, K., Pop, E., Bodor,
N., Langó, J., Roboz, J., Fast Atom Bombardment and Tandem
Mass Spectrometry of Quaternary Pyridinium Salt-Type Tryptophan
Derivatives, Org. Mass Spectrom., 28, 707-715, (1993). [PDF]
Langó, J., N-substituted Benzizothiazolinons: Oxygen Rearrangement
on Electron Impact, (Extended Abstract), 43rd ASMS Conf. on Mass
Spectrom., Allied Topics, (1995). [PDF]
Langó, J., Roboz, J., Salát, J., Yu, Q., Ma, L.,
Barta, I., Ott, I., Ambrus, G. and Simay, A., Identification of
Recombinant Hirudin Byproducts by Electrospray Ionization Mass Spectrometry,
European Mass Spectrometry, 2, 355-360, (1996). [PDF]
Lohse, C., Jaeger, L.L., Staimer, N., Sanborn, J. R., Jones, A.
D., Lango, J., Gee, S. J. and Hammock, B. D.2000.
Development of a Class-Selective Enzyme-Linked Immunosorbent
Assay for Mercapturic Acids in Human Urine, J. Agric. Food Chem,
48(12), 5913-5923. [PDF]
Inceoglu, B., Lango, J., Wu, J., Hawkins, P., Southern, J. and
Hammock, B. D. 2001. Isolation and characterization
of a novel type of neurotoxic peptide from the venom of the South
African scorpion Parabuthus transvaalicus (Buthidae), European Journal
of Biochemistry. 268 (20), 5407-5413. [PDF]
Pakenham, G., Lango, J., Bounarati, M., Morin, D. and Buckpitt,
A. 2002. Urinary Naphthalene Mercapturates as Biomarkers
of Exposure and Stereoselectivity of Naphthalene Epoxidation, Drug
Metabolism and Disposition, 30(3). [PDF]
Inceoglu A. Bora, Hayashida Yuki, Lango Jozsef, Ishida Andrew
T., Hammock, Bruce D. 2002. A single charged surface
residue modifies the activity of ikitoxin, a beta-type Na+ channel
toxin from Parabuthus transvaalicus. European Journal of Biochemistry
(), 269(22), 5369-5376. [PDF]
Giri Shri N., Wang Qingjian, Xie Yan, Lango Jozsef, Morin Dexter,
Margolin Solomon B., Buckpitt Alan R. 2002. Pharmacokinetics
and metabolism of a novel antifibrotic drug pirfenidone, in mice
following intravenous administration. Biopharmaceutics & Drug
Disposition. 23(5), 203-211. [PDF]
Bora Inceoglu, Jozsef Lango, Jie Jing, Lili Chen, Fuat Doymaz,
Isaac N. Pessah, and Bruce D. Hammock. 2003. One
scorpion, two venoms: Prevenom of Parabuthus transvaalicus acts
as an alternative type of venom with distinct mechanism of action.
Proc Nat Acad Sci USA. 100(3), 922-927. [PDF]
Voss, A. A., Lango, J., Ernst-Russell, M., Morin, D. and Pessah,
I. N. 2004. Identification of Hyperreactive Cysteines
within Ryanodine Receptor Type 1 by Mass Spectrometry. J. Biol.
Chem., 279, 34514-34520. [PDF]
Inceoglu B., J. Lango, I.N. Pessah , B.D. Hammock. 2005.
Three structurally related, highly potent, peptides from the venom
of Parabuthus transvaalicus possess divergent biological activity.Toxicon.
45(6):727-733. [PDF]
Colleen, Carkeet, Stephen R. Dueker, Jozsef Lango, Bruce A. Buchholz,
Joshua W. Miller, Ralph Green, Bruce D. Hammock, John R. Roth, and
Peter J. Anderson. 2006. Human vitamin B12 absorption
measurement by accelerator mass spectrometry using specifically
labeled 14C-cobalamin. PNAS, 103(15), 5694-5699. [PDF]
Inceoglu, Bora. Jozsef Lango, Alina Rabinovich, Paul Whetstone,
Bruce D. Hammock. 2006. The neutralizing effect
of a polyclonal antibody raised against the N- terminal eighteen-aminoacid
residues of birtoxin towards the whole venom of Parabuthus transvaalicus.
Toxicon, 47, 144-149.
[PDF]
Colleen, Carkeet, Stephen R. Dueker, Jozsef Lango, Bruce A. Buchholz,
Joshua W. Miller, Ralph Green, Bruce D. Hammock, John R. Roth, and
Peter J. Anderson. 2006. Human vitamin B12 absorption measurement
by accelerator mass spectrometry using specifically labeled 14C-cobalamin.
PNAS, 103(15), 5694-5699
Andrew J. Phimister, Jozsef Lango, Eun Hui Lee, Michael Ernst-Russell,
Hiroshi Takeshima, Jianjie Ma, Paul D. Allen, and Isaac N. Pessah.
2007. Conformation-dependent stability of junctophilin 1 (JP1) and
ryanodine receptor type 1 (RyR1) channel complex is mediated by
their hyper-reactive thiols. Journal of Biological Chemistry; 282:
8667 – 8677
Anderson, Peter J., Jozsef Lango, Colleen Carkeet, Audrey Britten,
Bernhard Kräutler, Bruce D. Hammock, and John R. Roth. 2008.
One pathway can incorporate either adenine or dimethylbenzimidazole
as -axial ligand of B12 cofactors in Salmonella enterica. J. Bacteriol.
190(4), 1160-1171.
Farzaneh Alihosseini, Kou-San Ju, Jozsef Lango, Bruce D. Hammock,
and Gang Sun. 2008. Antibacterial Colorants: Characterization of
Prodiginines and Their Applications on Textile Materials. Biotechnol.
Prog., 24, 742-747.
Patents
206824 Process for the production of a table crystallizing in the
monoclinic system, which contains light-, heat- and moisture-sensitive
active agents
P9700816 3(r)-3-amino-4-carboxy-butiraldehyde derivatives inhibiting
release of interleukin-1-beta
P9601528 Peptide derivatives of anticoagulant activity and pharmaceutical
compositions containing them
P9601527 Peptide-aldehyde derivatives of anticoagulant activity
and pharmaceutical compositions containing them
P9601526 Peptidyl-arginin-aldehyde derivatives of anticoagulant
activity and pharmaceutical compositions containing them
P9601525 Peptidyl-arginin-aldehyde derivatives of thrombin- and
xa-factor-inhibiting activity and pharmaceutical compositions containing
them
