Hua
Dong
Post-Doctoral
Researcher
Tel: +1-530-752-5109 (o) Fax: +1-530-752-1537
Email: hua.donghua@gmail.com
EDUCATION
• Ph.D. Aug. 2009, Department of Chemistry, Michigan State
University, East Lansing, MI
Advisers:
Dr. Greg. M. Swain (Department of Chemistry)
Dr. James J. Galligan (Department of Pharmacology & Toxicology)
• B.S. July, 2003,
Department of Chemistry, Xiamen University, Fujian, P.R.China
RESEARCH
EXPERIENCE
• Developed a reversed
phase HPLC technique coupled with Electro-Chemical detection (HPLC-EC)
for the analysis of neurotransmitters in organs and plasma
• Used HPLC-EC
method to quantitatively analyze small biological molecule norepinephrine
(NE) and its metabolite levels in heart and liver, as a function
of the disease state
• Established
an in-vitro electrochemical method coupled with biosensor to directly
record NE release from sympathetic nerves innervating blood vessels
• Studied the
alteration of NE release mechanisms and receptor function in hypertensive
animals
• Studied the
effects of oxidative stress on blood pressure and sympathetic nerve
activity with in vivo chronic antioxidant treatment
• Measured neurotransmitter,
serotonin, level from single cells to study the serotonin transporter
function in new born and adult guinea pigs
• Pharmacokinetics
of soluble epoxide hydrolase inhibitors
• Metabolomics
study of soluble epoxide hydrolase inhibitors on inflammatory disease
SELECTED PUBLICATIONS
1. Dong, H., Wang, S., Galligan, J.J. and Swain,
G.M. Effect of Neuropharmacological Drugs on the Detection of Norepinephrine
with Diamond Microelectrodes. (2009). J. Elctroanal.
Chem. 632, 20
2. Dong, H., Park, J., Fink, G., Galligan, J.J.
and Swain, G.M. Temperature dependent Differences in Sympathetic
Neuroeffector Transmission to Mesenteric Arteries and Veins. Submitted
to J Physiol.
3. Dong, H., Fink, G., Galligan, J.J. and Swain,
G.M. Impaired Adrenergic Neurotransmission to Mesenteric Arteries
but not Veins in DOCA-Salt Hypertensive Rats. In preparation.
4. Dong, H., Galligan, J.J. and Swain, G.M. O2-
Interacts with Pertussis Toxin-sensitive G-proteins to Disrupt a2
Adrenergic Receptor Function in Sympathetic Nerves Supplying Mesenteric
Arteries in DOCA-salt Hypertension. In preparation.
5. Liu, A., Dong, H., Galligan, J.J. and Swain,
G.M. Fast -Scan Cyclic Voltammetry with a Conically- Shaped Boron-Doped
Diamond Microelectrode. Submitted to Anal. Chem.
6. Demel, S., Dong, H. and Galligan, J.J. Role
of Oxidative Stress in the Altered Sympathetic Neurotransmissoin
in DOCA-salt Hypertension. Submitted to Hypertension.
7. Sangriri, S., Dong, H. Xu, H. and Galligan,
J.J. Impaired function of prejunctional A1 receptors in sympathetic
nerves supplying mesenteric arteries in DOCA-salt hypertension.
In preparation.
