Ayala Luria

 

 

Tel: (530) 752-5109

Fax: (530) 752-8995

 

Pharmacokinetic and pharmacodynamic specialist

 

Education

Ph.D. Bar Ilan University, Ramat Gan, Israel Biochemistry, Cell Biology & Molecular Biology
MS (Honors) Bar Ilan University, Ramat Gan, Israel Biochemistry
BS Bar Ilan University, Ramat Gan, Israel Biology

Business Education
1997-1998 MBA courses Bar Ilan University, Ramat Gan, Israel

Research

• Investigation of biochemical pathways associated with the oxidative transformation of arachadonic and linoleic acids by cytochrome P450 and soluble epoxide hydrolase (sEH).
• Pharmacokinetic evaluation of small molecules for drug development.
• Developing analytical methods based on LC/MS and GC/MS as a tool for drug pharmacokinetic evaluation.

Past Research:

• Investigated the role of nuclear transcription receptors during development using molecular biology techniques and in vivo genetic manipulation.
• Examine small molecule effect on reporter gene assay in Xenopus laevis cell lines and transgenic embryos in order to explore bioactive ligands for the orphan nuclear receptor super family.
• Characterized lipid-enriched plasma membrane microdomains in amphibian eggs.
• Subcellular isolation of cell membranes and characterization of lipid content, membrane phase transition, protein content, and cellular signaling of plasma membrane proteins.
• Developed a unique technique to isolate plasma membrane microdomains using non-detergent conditions.
• Characterized PKC pathway during sperm-egg interaction, and categorized G-proteins isoforms involved in sperm exocytosis.
• Characterization of P2X and P2Y purinoceptors in sperm, and their cellular signaling during sperm exocytosis.

Honors and Awards

2001 Best Poster Award, “Fertilization and activation during development,” Gordon Conference, Holderness School, Plymouth, NH.
1999 Research Award, “Differential localization of conventional protein
kinase C isoforms during mouse oocyte development,” IHEL Fertility Fund, Israel.
1997 Research Award, “Induction of bovine sperm acrosome reaction by pertussis toxin,” IHEL Fertility Fund, Israel.
1994 Rotary Award for High Achievements, Israel.
1988, 1990 Bar Ilan Scholarship, Bar Ilan University, Israel.

Teaching Experience

2001- Present Student Supervisor, University of California, Davis
Mentor undergraduate students for independent research.
1991-1999 Teaching Assistant, Life Sciences Faculty, Bar-Ilan University, Israel
Topics: biochemistry, electron microscopy, cell biology, computer applications.

Publications

Luria A and J.D Furlow (2004) Spatiotemporal retinoid-X receptor activation detected in live vertebrate embryos. Proc Natl Acad Sci, USA, 101 (24): 8987-8992.

Luria A., Yang H., Chu Y., and J.D Furlow (2004) Activation of the nuclear receptor TR??in transgenic Xenopus embryos. Submitted

Luria A., Vegelyte-Avery V., Stith B., Tsvetkova N., Wolkers W. F., Crowe J. H., Tablin F., and R, Nuccitelli (2002) Detergent-free domain isolated from Xenopus egg plasma membrane with properties similar to those of detergent-resistant membranes. Biochemistry, 41:13189-13197.

Luria A., Rubinstein S., Lax Y., and Breitbart H. (2002) Extracellular adenosine triphosphate stimulates acrosomal exocytosis in bovine spermatozoa via P (2) purinoceptor. Biology of Reproduction 66: 429-437.

Su Y.Q., Rubinstein S., Luria A., Lax Y and Breitbart H. (2001) Involvement of MEK-mitogen-activated protein kinase pathway in follicle stimulating hormone-induced but not spontaneous meiotic resumption of mouse oocytes. Biology of Reproduction 65: 358-365.

Luria A., Tennenbaum T., Rubinstein S., and Breitbart H. (2000) Differential localization of conventional protein kinase C isoforms during mouse oocyte development. Biology of Reproduction 62: 1564-1569.

Sun Q.Y., Luria A., Rubinstein S., and Breitbart H. (1998) Protein kinase inhibitors induce the interphase transition by inactivating mitogen- activated protein kinase in mouse eggs. Zygote 6: 277-28.